Große Research Group
The doubling of genetic information, namely DNA replication, is a central aspect of all living organisms. Errors occurring during DNA replication may lead to cancer or premature aging of the cell and/or the whole organism. The Große group is interested in basic aspects of DNA replication, its regulation and the prevention of errors that might occur during this process.
The questions we are addressing are:
- How is the initiation of replication regulated and how is it stopped when something goes awry?
- What happens to errors that are introduced during this process?
- What happens to replication forks that are halted in front of a damaged site?
- How are stalled replication forks started again?
- What are the signals that cause cell death when damaged sites are irreparable?
We intend that our research contributes to a better understanding of how cells prevent replication errors and thereby escape premature senescence and ultimately cell death.