Ermolaeva Research Group
We recently discovered that transient activation of innate immune response by DNA damage or probiotic feeding leads to elevated systemic stress resistance in the nematode C. elegans. Stress resistance is achieved through increased activity of the ubiquitin proteasome system (UPS) which maintains cellular proteomes in a "healthier" state prior to stress exposure. Our findings excitingly indicate that simple cost effective interventions could be used to promote cell maintenance and survival during stress.
In the future we aim at deeper understanding of molecular mechanisms linking protective stimuli to organ maintenance; thereby we will identify potential molecular targets for stress-protective therapeutic modulation. We will also search for novel compounds and genetic pathways linked to improved tissue homeostasis under stress in two model systems: C. elegans and murine primary cells. We will further study interplay between immunity and protein quality control in nematodes and cell culture. We will evaluate our findings in mouse models of tissue degeneration and potentially take first steps in creating stress-protective human therapies.
Current Projects we are working on are:
- Studying effects of radiation hormesis in murine models of organ degeneration
- High throughput screens for mediators of stress tolerance in human cells
- Genome wide stress tolerance screens in C. elegans
- Studying effects of diet, exercise and inflammation on metazoan longevity and homeostasis (by using C. elegans as a model organism)
|Maria Ermolaeva||+49 3641 firstname.lastname@example.org||Group Leader|
|Jose Miguel Chin Chan||+49 3641 email@example.com||Postdoc|
|Lilia Pinela Soares Espada||+49 3641 firstname.lastname@example.org||Postdoc|
|Prerana Shrikant Chaudhari||+49 3641 email@example.com||Doctoral Student|
|Oleksandr Dakhovnik||+49 3641 firstname.lastname@example.org||Doctoral Student|
|Tetiana Poliezhaieva||+49 3641 email@example.com||Doctoral Student|
|Yvonne Schaub||+49 3641 firstname.lastname@example.org||Technical Assistant|