Jasper Cooperation Group
Our lab studies how diverse inputs such as growth and stress signaling pathways (e.g. Insulin, JNK), metabolic processes and proteasome stress influence stem cells and how these inputs change during aging.
Furthermore, our lab is interested in the intrinsic controls that govern the unique identity of adult stem cells. We have discovered several key players that control stem cell maintenance and differentiation and are continuing to expand our knowledge on the transcriptional network that governs adult stem cell identity.
We are collaborating with the groups Ori and Rudolph to find common mechanisms in organismal aging at the stem cell level. To address our questions, the lab uses a wide range of molecular, genetic, genomic and imaging techniques such as FACS, RNA-Seq, clonal analysis of stem cell division, confocal imaging and organoid culture.