Wang Research Group

Publications

2017

  • XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
    Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GMS, McKinnon PJ, Wang ZQ, Wagner JD, Care4Rare Canada Consortium, Yoon G, Caldecott KW
    Nature 2017, 541(7635), 87-91
  • Hepatic Tmem30a deficiency causes intrahepatic cholestasis by impairing expression and localization of bile salt transporters.
    Liu L, Zhang L, Zhang L, Yang F, Zhu X, Lu Z, Yang Y, Lu H, Feng L, Wang Z, Chen H, Yan S, Wang L, Ju Z, Jin H, Zhu X
    Am J Pathol 2017, 187(12), 2775-87
  • The E3 ubiquitin ligase APC/C(C)(dh1) degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.
    Liu X, Zong W, Li T, Wang Y, Xu X, Zhou** ZW, Wang** ZQ
    EMBO J 2017 (epub ahead of print) ** co-corresponding authors
  • The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing's sarcoma cell line.
    Marx C, Marx-Blümel L, Lindig N, Thierbach R, Hoelzer D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J
    Invest New Drugs 2017 (epub ahead of print)
  • The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis.
    Nathan A, Reinhardt P, Kruspe D, Jörß T, Groth M, Nolte H, Habenicht A, Herrmann J, Holschbach V, Toth B, Krüger M, Wang ZQ, Platzer M, Englert C
    Hum Mol Genet 2017, 26(9), 1694-705
  • Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells.
    Riemann M, Andreas N, Fedoseeva M, Meier E, Weih D, Freytag H, Schmidt-Ullrich R, Klein U, Wang ZQ, Weih F
    J Autoimmun 2017, 81, 56-67
  • The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.
    Schneble N, Müller J, Kliche S, Bauer R, Wetzker R, Böhmer FD, Wang ZQ, Müller JP
    Glia 2017, 65(2), 416-28
  • PARPing for Balance in the Homeostasis of Poly(ADP-ribosyl)ation.
    Schuhwerk H, Atteya R, Siniuk K, Wang ZQ
    Semin Cell Dev Biol 2017, 63, 81-91
  • Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.
    Schuhwerk H, Bruhn C, Siniuk K, Min W, Erener S, Grigaravicius P, Krüger A, Ferrari E, Zubel T, Lazaro D, Monajembashi S, Kiesow K, Kroll T, Bürkle A, Mangerich A, Hottiger M, Wang ZQ
    Nucleic Acids Res 2017, 45(19), 11174-92
  • Lysine Acetylation and Deacetylation in Brain Development and Neuropathies.
    Tapias A, Wang ZQ
    Genomics Proteomics Bioinformatics 2017, 15(1), 19-36