Große Research Group

Publications

2017

  • Toxic effects of zinc ions on kinesin - Potential molecular cause of impaired intracellular transport.
    Böhm KJ
    Toxicol Lett 2017 (epub ahead of print)
  • N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization.
    Prinz H, Ridder AK, Vogel K, Böhm KJ, Ivanov I, Ghasemi J, Aghaee E, Müller K:
    J Med Chem 2017, 60(2), 749-66
  • Cdc45-induced loading of human RPA onto single-stranded DNA.
    Szambowska A, Tessmer I, Prus P, Schlott B, Pospiech H, Grosse F
    Nucleic Acids Res 2017 (epub ahead of print)

2016

  • S100A11 plays a role in homologous recombination and genome maintenance by influencing the persistence of RAD51 in DNA repair foci.
    Foertsch F, Szambowska A, Weise A, Zielinski A, Schlott B, Kraft F, Mrasek K, Borgmann K, Pospiech** H, Grosse F, Melle** C
    Cell Cycle 2016, 15(20), 2766-79 ** co-corresponding authors
  • DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.
    Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L
    Proc Natl Acad Sci U S A 2016, 113(30), E4311-9
  • Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6.
    Itkonen HM, Kantelinen J, Vaara M, Parkkinen S, Schlott B, Grosse F, Nyström M, Syväoja JE, Pospiech H
    FEBS Lett 2016, 590(23), 4233-41
  • Cdc45 is limiting for replication initiation in humans.
    Köhler C, Koalick D, Fabricius A, Parplys AC, Borgmann K, Pospiech H, Grosse F
    Cell Cycle 2016, 15(7), 974-85 ** co-senior authors
  • High-Content Microscopy Analysis of Subcellular Structures: Assay Development and Application to Focal Adhesion Quantification.
    Kroll* T, Schmidt* D, Schwanitz G, Ahmad M, Hamann J, Schlosser C, Lin YC, Böhm KJ, Tuckermann J, Ploubidou A
    Curr Protoc Cytom 2016, 77, 12.43.1-12.43.44 * equal contribution
  • Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
    Obermeier K, Sachsenweger J, Friedl TWP, Pospiech H, Winqvist R, Wiesmüller L
    Oncogene 2016, 35(29), 3796-806
  • TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress.
    Pai GM, Zielinski A, Koalick D, Ludwig K, Wang ZQ, Borgmann K, Pospiech H, Rubio I
    Oncotarget 2016, 7(51), 85365-80