Former Than Research Group (Until 2015)

Publications

2018

  • X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
    Dahms SO, Hardes K, Steinmetzer T, Than ME
    Biochemistry 2018, 57(6), 925-34

2017

  • Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
    Dahms SO, Jiao GS, Than ME
    ACS Chem Biol 2017, 12(5), 1211-6
  • Optimization of Substrate-Analogue Furin Inhibitors.
    Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T
    ChemMedChem 2017, 12(23), 1953-68

2016

  • Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis.
    Coburger I, Schaub Y, Roeser D, Hardes K, Maeder P, Klee N, Steinmetzer T, Imhof D, Diederich WE, Than ME
    Microbiologyopen 2016, 5(4), 637-46
  • The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
    Dahms SO, Creemers JWM, Schaub Y, Bourenkov GP, Zögg T, Brandstetter H, Than ME
    Sci Rep 2016, 6, 34303.doi:10.1038/srep303
  • Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
    Dahms* SO, Arciniega* M, Steinmetzer T, Huber** R, Than** ME
    Proc Natl Acad Sci U S A 2016, 113(40), 11196-201 * equal contribution, ** co-corresponding authors

2015

  • Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
    Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME
    Acta Crystallogr D Biol Crystallogr 2015, 71(Pt 3), 494-504
  • Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA.
    Dienemann C, Coburger I, Mehmedbasic A, Andersen OM, Than ME
    Biochemistry 2015, 54(15), 2490-9
  • Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.
    Fittler H, Depp A, Avrutina O, Dahms SO, Than ME, Empting M, Kolmar H
    Chembiochem 2015, 16(17), 2441-4
  • Novel Furin Inhibitors with Potent Anti-infectious Activity.
    Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T
    ChemMedChem 2015, 10(7), 1218-31