Herrlich Research Group



  • Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma.
    Li H, Frappart* L, Moll* J, Winkler* A, Kroll T, Hamann J, Kufferath I, Groth M, Taudien S, Schütte M, Yaspo ML, Heuer H, Lange BMH, Platzer M, Zatloukal K, Herrlich P, Ploubidou A
    Cancer Res 2016, 76(21), 6382-95 * equal contribution
  • Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility.
    Parra* LM, Hartmann* M, Schubach S, Ma J, Herrlich** P, Herrlich** A
    Sci Rep 2016, 6, 37464 * equal contribution, ** co-senior authors


  • Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 [CD44] and of Neuregulin-1 requires Substrate Dimerization.
    Hartmann M, Parra LM, Ruschel A, Lindner C, Morrison H, Herrlich** A, Herrlich** P
    J Biol Chem 2015, 290(28), 17041-54 ** co-senior authors, 2015 Best of jbc Papers of the Week Winner
  • Tumor suppressor NF2 blocks cellular migration by inhibiting ectodomain cleavage of CD44.
    Hartmann* M, Parra* LM, Ruschel A, Schubert S, Li Y, Morrison H, Herrlich** A, Herrlich** P
    Mol Cancer Res 2015, 13(5), 879-90 * equal contribution, ** co-senior authors
  • RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility.
    Li H, Moll J, Winkler A, Frappart L, Brunet S, Hamann J, Kroll T, Verlhac MH, Heuer H, Herrlich P, Ploubidou A
    Biol Open 2015, 4(4), 562-71

Best Paper

The JBC paper on Ectodomain Cleavage has been selected as one of the best JBC papers of the year.